•  Validation of the global strategy : correct prediction of the precise site of recognition between two partners (Rad53 and Ptc2) from the knowledge of the binding specificities [Leroy et al] et [Guillemain et al]. Application to the dissection of the regulation network involved in the cell cycle arrest after double strand DNA damage. 

•  Structure of the tandem Tudor regulatory domain of 53BP1. Characterization of its canonical binding sites with methylated amino acids and DNA [Charier et al].

•  Correct prediction of binding specificity from high to medium resolution structure (validation of scoring methods). Structure prediction optimisation is under optimisation [Guerois et al, Becker et al].